In a recent phase IIb PARADIGM trial, a novel treatment candidate for amyotrophic lateral sclerosis (ALS) called PrimeC has shown promising results. This formulation, which combines two FDA-approved drugs, ciprofloxacin and celecoxib, met its primary safety and secondary endpoints. The study results were presented by Merit Cudkowicz, MD, MSc, at the American Academy of Neurology
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Antipsychotic medications have long been a controversial subject when it comes to treating dementia patients. A recent population-based matched cohort study from the U.K. shed light on the significant risks associated with the use of antipsychotics in dementia patients. The study revealed that individuals prescribed antipsychotics were at a substantially higher risk of suffering from
Duchenne muscular dystrophy (DMD) is a devastating and incurable genetic disorder that primarily affects boys, leading to muscle weakness and ultimately respiratory failure. However, recent research has shown promising results with exon-skipping therapies like viltolarsen, which aims to bypass certain mutated genes and produce a functional form of dystrophin. The open-label, phase II Galactic53 trial
In a disturbing turn of events, Dallas anesthesiologist Raynaldo Rivera Ortiz Jr., MD, was found guilty of injecting a nerve-blocking agent and other drugs into IV bags, resulting in the death of a coworker and multiple cardiac emergencies involving patients. This shocking incident highlights the grave consequences of medical malpractice and the need for stringent
The frustration over the prior authorization burden for newer, highly effective cholesterol-lowering drugs is still prevalent in the medical community, as expressed by Christie Ballantyne, MD, from Baylor College of Medicine. Despite some improvements in access, physicians continue to face challenges in prescribing these medications to patients who could benefit from them. This issue highlights
Imagine being a 28-year-old woman with no prior health issues, presenting with a mysterious mass growing in the corner of your eye. This was the perplexing situation faced by a patient who sought medical care at Cliniques Universitaires Saint-Luc in Brussels. The woman had been on a humanitarian mission in the Democratic Republic of Congo
FDA Commissioner Robert Califf has come under intense scrutiny from Republican lawmakers for his handling of various issues, including the authorization of COVID-19 vaccines. During a recent hearing, there were strong criticisms leveled against the agency’s decision to grant emergency use authorization for these vaccines. Some lawmakers expressed concerns that the vaccines did not stop
When it comes to the privacy and security of personal information online, hospital websites should be held to high standards. However, a recent analysis of 100 hospital websites revealed some concerning findings. Researchers found that nearly all of these hospital websites transferred user information to third parties, yet almost a third of them did not
In a recent small pilot study, the combination of chemotherapy and immunotherapy showed promising results for borderline resectable pancreatic cancer. The phase I/II trial involved preoperative treatment with modified FOLFIRINOX plus nivolumab, resulting in favorable rates of R0 resection, as well as a median progression-free survival of 21.9 months and median overall survival of 34.6
The relationship between obstructive sleep apnea (OSA) and COVID-19 treatment outcomes has been a topic of interest, with a recent study shedding light on this connection. This retrospective study, conducted by Bharati Prasad, MD, MS, and colleagues at the University of Illinois at Chicago, explored the impact of OSA on the use of non-invasive ventilation